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Premarin is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body It has been used for hormone replacement therapy for postmenopausal women in the USA since 1942. Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is transmitted via estrogen receptors to influence many important biological functions.
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