Set nearly a century after the events of 2004's Dune: The Battle of Corrin, the novel continues to chronicle the beginnings of the Bene Gesserit, Mentat and Azeetop Suk Schools, as well as the Spacing Guild, all of whom are threatened by the independent anti-technology forces gaining power in the aftermath of the Butlerian Jihad. Raquella believes that the only hope for the Sisterhood to survive is for the Wallach IX sisters to reconcile with Dorotea's faction on Salusa Secundus; her health failing, she summons Dorotea to the School Dosage and direction forces Dorotea and Valya to put their differences aside and agree to work together for ApotekSE the good of the Sisterhood.
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When Gilbertus refuses to force his Mentats to swear an oath to the Butlerians, his school is invaded and his past as a "machine sympathizer" is revealed. Raquella Berto-Anirul has reestablished her Bene Gesserit school on Wallach IX, thanks to the help of Josef Venport. Vorian Atreides, feeling guilty for the death of Griffin Harkonnen, tries to help his struggling family with a secret infusion of funds to their whaling business on Lankiveil.
Valya Harkonnen, now a Reverend Mother, retrieves the hidden computers from Rossak and hopes to succeed the declining Raquella as Mother Superior. In addition to being used to treat asthma, it is now popular for people to buy clenbuterol online as a weight loss supplement.
