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According to the FDA, tramadol is only approved for the usage of pain treatment. Pain which usually drives by accident or severe injury their doctor provides tramadol high dosage such as tramadol 50mg to tramadol 200mg.

However, there are multiple uses of Tramadol, known as "off-label uses of Tramadol."

Anti-depressant "Off-label use of Tramadol'

According to the result of John A. Bumpus, in the study of "Low-Dose Tramadol as an Off-Label Antidepressant: A Data Mining Analysis from the Patients' Perspective." There are multiple off-label uses of tramadol

He analyses tramadol effectiveness in terms of anxiety treatment. And he compared tramadol with other 40 high anti-depressants. Surprisingly recording tramadol is the strongest painkiller with 94.6% of patients who gave high ratings to tramadol 200mg.

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